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Protein Coding Gene : Pank2 pantothenate kinase 2
Primary Identifier  MGI:1921700 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  74450
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables pantothenate kinase activity. Involved in coenzyme A biosynthetic process. Acts upstream of or within several processes, including aerobic respiration; regulation of mitochondrial membrane potential; and spermatid development. Located in cytosol and mitochondrion. Is active in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Orthologous to human PANK2 (pantothenate kinase 2).
PHENOTYPE: Homozygous null mice display male infertility, arrested spermatogenesis, azoospermia, reduced female fertility, and retinal degeneration. [provided by MGI curators]
  • synonyms:
  • Pank2,
  • pantothenate kinase 2,
  • 4933409I19Rik,
  • AI642621,
  • expressed sequence AI642621,
  • MGI:2139023,
  • RIKEN cDNA 4933409I19 gene
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Features --> Cross References

Genome

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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

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Function

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Homology

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Interactions

5 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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