Primary Identifier | MGI:1920997 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 73747 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to be located in chromosome. Predicted to be active in site of double-strand break. Orthologous to human SHLD1 (shieldin complex subunit 1). PHENOTYPE: Mice homozygous for a null allele show defects in IgG1 class switch recombination but mice are viable and do not show any overt phenotypes. [provided by MGI curators] |