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Protein Coding Gene : Pcsk2 proprotein convertase subtilisin/kexin type 2
Primary Identifier  MGI:97512 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  18549
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables serine-type endopeptidase activity. Involved in nervous system development and protein processing. Acts upstream of or within proteolysis. Located in extracellular space. Is active in secretory granule. Is expressed in brain; endocrine gland; future brain; and gut. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2).
PHENOTYPE: Mice homozygous for disruptions of this gene display abnormalities in the maturation of peptide hormones leading to reduced female fertility, increased blood pressure on a high salt diet, and abnormal glucose metabolism. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-13300,
  • MGD-MRK-13192,
  • Nec-2,
  • AI839700,
  • proprotein convertase subtilisin/kexin type 2,
  • MGI:1918009,
  • prehormone processing proteinase,
  • Phpp-2,
  • Nec2,
  • 6330411F23Rik,
  • PC2,
  • MGD-MRK-12803,
  • RIKEN cDNA 6330411F23 gene,
  • neuroendocrine convertase 2,
  • MGD-MRK-12805,
  • expressed sequence AI839700,
  • MGI:2139063,
  • SPC2,
  • prohormone convertase 2,
  • Pcsk2
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