| Primary Identifier | MGI:1921778 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 74528 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in mitochondrial DNA repair and mitochondrial DNA replication. Located in mitochondrion. Is expressed in cerebral cortex ventricular layer. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 11. Orthologous to human MGME1 (mitochondrial genome maintenance exonuclease 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit depletion and deletion of mitochondrial DNA, reduced mitochondrial transcription and mild anemia without developing progeria. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
