| Primary Identifier | MGI:1338039 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 107586 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including negative regulation of epithelial to mesenchymal transition; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including circulatory system development; positive regulation of keratinocyte differentiation; and tube morphogenesis. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; head surface ectoderm; and otocyst. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to human OVOL2 (ovo like zinc finger 2). PHENOTYPE: Embryos homozygous for a null allele are small and die at E9.5-E10.5 with an open neural tube, impaired extraembryonic and embryonic vascularization, abnormal cardiogenesis and placental defects. Homozygotes for another null allele die by E10.5 with brain, neural crest, gut tube and heart anomalies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
