| Primary Identifier | MGI:104664 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 21407 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and bHLH transcription factor binding activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of stem cell differentiation; and stem cell population maintenance. Acts upstream of or within several processes, including epithelial cell differentiation; paraxial mesoderm development; and post-anal tail morphogenesis. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including early embryo; foregut-midgut junction; genitourinary system; paraxial mesenchyme; and sensory organ. Orthologous to human TCF15 (transcription factor 15). PHENOTYPE: In homozygotes for a targeted null mutation, cells of the paraxial mesoderm fail to form epithelia resulting in disrupted somites, patterning defects of the axial skeleton, peripheral nerves, and skeletal muscles, and perinatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
