| Primary Identifier | MGI:1890410 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 60525 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables CoA-ligase activity; chromatin binding activity; and transcription coactivator activity. Involved in long-term memory. Acts upstream of or within acetyl-CoA biosynthetic process. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). PHENOTYPE: Mice homozygous for a knock-out allele are resistant to acute renal injury and inflammation in an LPS-induced sepsis model and show reduced IL1beta production and decreased NLRP3 activation-mediated pyroptosis of renal tubular epithelial cells in response to LPS challenge. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
