| Primary Identifier | MGI:1917720 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 70470 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA polymerase II complex binding activity and identical protein binding activity. Predicted to be involved in several processes, including RNA metabolic process; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription preinitiation complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and mammary gland. Orthologous to human RPRD1B (regulation of nuclear pre-mRNA domain containing 1B). PHENOTYPE: Mice homozygous for a conditional allele activated in intestinal cells exhibit increased prenatal mortality, small body size, enlarged and thickened large intestine crypts, impaired proliferation and differentiation of Lgr5+ stem cells, and increased DSS-induced mortality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
