Primary Identifier | MGI:3611233 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 269389 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin DNA binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; lens epithelium; notochord; retina; and spleen. Orthologous to human TOX2 (TOX high mobility group box family member 2). PHENOTYPE: Mice homozygous for a null allele show defective/reduced T follicular helper cell differentiation. [provided by MGI curators] |