| Primary Identifier | MGI:2444508 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 228859 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables diacylglycerol binding activity and triglyceride binding activity. Involved in several processes, including intracellular triglyceride homeostasis; lipid droplet formation; and positive regulation of sequestering of triglyceride. Acts upstream of or within sequestering of triglyceride. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2). PHENOTYPE: Homozygous knockout is embryonic lethal, while heterozygous KO increases survival after and reduces susceptibility to pressure overload-induced heart failure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
