Primary Identifier | MGI:1921864 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 74614 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in several processes, including cellular response to estrogen stimulus; positive regulation of osteoclast differentiation; and positive regulation of osteoclast proliferation. Acts upstream of or within positive regulation of macrophage fusion. Predicted to be located in membrane. Is expressed in mandible; maxilla; metanephros; and testis. Orthologous to human OCSTAMP (osteoclast stimulatory transmembrane protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit defective osteoclast fusion but normal skeletal paramaters. [provided by MGI curators] |