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Protein Coding Gene : Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1

Primary Identifier  MGI:96666 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  16500
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables delayed rectifier potassium channel activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of insulin secretion; and positive regulation of long-term synaptic depression. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including adipose tissue; brain; cardiovascular system; genitourinary system; and gut. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1).
PHENOTYPE: Mice homozygous for a null allele show reduced fasting glucose levels, hyperinsulinemia, improved glucose tolerance, and enhanced insulin secretion. Mice homozygous for another null allele exhibit loss of photoreceptors with increased apoptosis. [provided by MGI curators]
  • synonyms:
  • potassium voltage gated channel, Shab-related subfamily, member 1,
  • MGD-MRK-11579,
  • Shab,
  • Kcnb1,
  • K<+> channel, delayed rectifier, subtype 1, gene 1 [Drosophila Shab homolog],
  • Kv2.1,
  • Kcr1-1,
  • MGD-MRK-11570,
  • MGD-MRK-14396

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