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Protein Coding Gene : Pmepa1 prostate transmembrane protein, androgen induced 1
Primary Identifier  MGI:1929600 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  65112
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable R-SMAD binding activity and WW domain binding activity. Involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in endosome membrane. Predicted to be active in Golgi membrane and early endosome membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Orthologous to human PMEPA1 (prostate transmembrane protein, androgen induced 1).
PHENOTYPE: Mice homozygous for a null allele exhibit increased bone volume, decreased osteoclast cell number, deduction in eroded surface per bone surface, and decreased bone resorption. [provided by MGI curators]
  • synonyms:
  • 2210418I02Rik,
  • RIKEN cDNA 2210418I02 gene,
  • N4wbp4,
  • STAG1,
  • prostate transmembrane protein, androgen induced 1,
  • Tmepai,
  • transmembrane, prostate androgen induced RNA,
  • PMEPA1,
  • expressed sequence AW455466,
  • AW455466,
  • MGI:2139348,
  • MGI:1917408,
  • Pmepa1
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