| Primary Identifier | MGI:98241 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 20257 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium-dependent protein binding activity and tubulin binding activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; regulation of microtubule polymerization or depolymerization; and regulation of neuron projection development. Located in growth cone. Is expressed in several structures, including alimentary system; autopod; genitourinary system; nervous system; and nose. Used to study amyotrophic lateral sclerosis; motor peripheral neuropathy; and neuropathy. Orthologous to human STMN2 (stathmin 2). PHENOTYPE: Mice homozygous for a null allele develop early-onset sensory and motor neuropathy with behavioral deficits, reduced compound muscle action potentials, severe distal neuromuscular junction (NMJ) denervation of fast-fatigable motor units, and intraepidermal nerve fiber loss. Heterozygous null mice show a progressive, motor-selective neuropathy with distal NMJ denervation but no sensory defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
