| Primary Identifier | MGI:1913621 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 66371 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including proteolysis involved in protein catabolic process; regulation of cell cycle process; and vacuolar transport. Predicted to be located in several cellular components, including Flemming body; bounding membrane of organelle; and kinetochore microtubule. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in cytoplasmic side of plasma membrane and multivesicular body. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; lung; and lymph node. Orthologous to human CHMP4C (charged multivesicular body protein 4C). PHENOTYPE: Aging mice homozygous for a knock-out allele exhibit impaired social recognition and an increase in miniature excitatory postsynaptic currents (mEPSCs), suggesting synaptic hyperactivity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
