| Primary Identifier | MGI:99260 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 18759 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity. Involved in cellular response to insulin stimulus; positive regulation of D-glucose import; and positive regulation of protein localization to plasma membrane. Acts upstream of or within actin filament organization; establishment of apical/basal cell polarity; and eye photoreceptor cell development. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and brush border. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Used to study abdominal obesity-metabolic syndrome; obesity; and type 2 diabetes mellitus. Orthologous to human PRKCI (protein kinase C iota). PHENOTYPE: Homozygous inactivation of this gene leads to complete embryonic lethality. Muscle-specific deletion of this gene impairs glucose transport and induces metabolic and diabetic syndromes. Podocyte-specific deletion leads to altered podocyte architecture, proteinuria, and accelerated renal failure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
