Primary Identifier | MGI:1861453 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 56456 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Involved in several processes, including positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Acts upstream of or within blastocyst formation and chromatin remodeling. Located in nucleus. Part of SWI/SNF complex and npBAF complex. Is expressed in several structures, including central nervous system; genitourinary system; lung; nose; and tooth. Orthologous to human ACTL6A (actin like 6A). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality before E6.5. Mice homozygous for a conditional allele activated in hematopoietic cells exhibit bone marrow failure and premature death. [provided by MGI curators] |