Primary Identifier | MGI:1919857 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 72607 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including BAT3 complex binding activity; peptidase activity; and proteasome binding activity. Predicted to be involved in several processes, including protein K63-linked deubiquitination; protein stabilization; and regulation of catabolic process. Predicted to act upstream of or within protein K29-linked deubiquitination and protein K6-linked deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human USP13 (ubiquitin specific peptidase 13). PHENOTYPE: Mice homozygous for a null allele exhibit increased susceptibility to LPS- or Pseudomonas aeruginosa (strain PA103)- induced lung inflammation and injury. [provided by MGI curators] |