Primary Identifier | MGI:1916672 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 58869 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable intracellularly cyclic nucleotide-activated monoatomic cation channel activity; peroxisome matrix targeting signal-1 binding activity; and small GTPase binding activity. Acts upstream of or within maintenance of protein location and regulation of membrane potential. Located in cytoplasm and dendrite. Is expressed in brain; cerebral cortex; and retina outer nuclear layer. Orthologous to human PEX5L (peroxisomal biogenesis factor 5 like). PHENOTYPE: Mice homozygous for a targeted mutation lacking isoform b exhibit reduced hyperpolarization-activated current in CA1 pyramidal neuron, impaired motor learning, impaired nest-building, decreased startle reflex, and decreased depression-related behaviors. [provided by MGI curators] |