| Primary Identifier | MGI:109382 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 12457 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA binding activity and poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation; and regulation of gene expression. Acts upstream of or within P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body; nucleus; and perinuclear region of cytoplasm. Is expressed in 2-cell stage embryo; central nervous system; and retina. Orthologous to human NOCT (nocturnin). PHENOTYPE: Mice homozygous for a null allele are resistant to diet-induced obesity and fatty liver development, show increased circulating glucose levels and increased insulin sensitivity on a standard diet and have impaired glucose tolerance on a high fat diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
