| Primary Identifier | MGI:1890077 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 56458 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to nitric oxide; negative regulation of fat cell differentiation; and negative regulation of insulin secretion. Acts upstream of or within several processes, including insulin receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; and positive regulation of biosynthetic process. Located in cytoplasm. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). PHENOTYPE: Homozygous null embryos die at E10.5-E11.5 from vasculature defects. Heterozygote null mice have slightly elevated glycogen levels. Conditionally targeted homozygotes display hemangiomas or defects in naïve T cell homeostasis depending on the targeted cell type. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
