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Protein Coding Gene : Arhgef26 Rho guanine nucleotide exchange factor 26
Primary Identifier  MGI:1918053 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  622434
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within endothelial cell morphogenesis and ruffle assembly. Is expressed in pons ventricular layer. Orthologous to human ARHGEF26 (Rho guanine nucleotide exchange factor 26).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit defective activation of RhoG and reduced membrane protrusion after ICAM-1 clustering. [provided by MGI curators]
  • synonyms:
  • 8430436L14Rik,
  • expressed sequence AI303572,
  • expressed sequence AW491953,
  • RIKEN cDNA 8430436L14 gene,
  • Arhgef26,
  • Rho guanine nucleotide exchange factor 26,
  • RIKEN cDNA 4631416L12 gene,
  • AW491953,
  • AI303572,
  • MGI:2139660,
  • MGI:2139988,
  • 4631416L12Rik,
  • MGI:1918810
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Features --> Cross References

Genome

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

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Homology

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Interactions

13 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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