| Primary Identifier | MGI:1914199 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 66949 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Involved in innate immune response and negative regulation of viral entry into host cell. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and skin. Orthologous to human TRIM59 (tripartite motif containing 59). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality associated with failure of primary germ layer formation, small embryonic epiblasts, absent mesoderm, and abnormal inner cell mass differentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
