Primary Identifier | MGI:1858203 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 53868 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTP binding activity; GTPase activity; and myosin V binding activity. Involved in epithelial cell morphogenesis. Predicted to be located in cytoplasmic vesicle; plasma membrane; and pseudopodium. Predicted to be active in Golgi apparatus and recycling endosome. Is expressed in gut; nasal cavity epithelium; skin; submandibular gland primordium; and urinary system. Orthologous to human RAB25 (RAB25, member RAS oncogene family). PHENOTYPE: On a 129 background, virgin female homozygotes older than 10 months of age develop vaginal cancer while both male and female homozygotes develop distal esophageal stricture due to squamous cell hyperplasia. [provided by MGI curators] |