| Primary Identifier | MGI:1934229 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 84505 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity; histone H3K9 methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation-dependent constitutive heterochromatin formation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and transposable element silencing by heterochromatin formation. Acts upstream of or within bone development; inner cell mass cell proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1-cell stage embryo; central nervous system; heart; long bone; and oocyte. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). PHENOTYPE: Homozygous inactivation of this locus results in peri-implantation lethality. Inner cell mass growth is impaired in null blastocysts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
