| Primary Identifier | MGI:109605 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 14270 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including filopodium assembly; nervous system development; and positive regulation of GTPase activity. Located in cytosol; phagocytic vesicle; and postsynaptic membrane. Is active in dendritic spine; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; heart; sensory organ; and spleen. Orthologous to human SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2). PHENOTYPE: Mice homozygous for a hypomorphic gene trap allele are born at below the expected Mendelian ratio, but are otherwise viable. Layer 5 cortical pyramidal neurons exhibit an increased density of dendritic spines with a decreased spine head width and increased length of spine necks. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
