Primary Identifier | MGI:1915095 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 67845 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and protein K63-linked ubiquitination. Located in cytosol. Is expressed in central nervous system and genitourinary system. Orthologous to human RNF115 (ring finger protein 115). PHENOTYPE: Mice homozygous for a null allele exhibit hypo- and hyper-sensitivity to EMCV and HSV-1 infection, respectively. [provided by MGI curators] |