Primary Identifier | MGI:2653612 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 229715 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables potassium channel regulator activity. Involved in positive regulation of potassium ion transmembrane transport. Acts upstream of or within positive regulation of synapse assembly. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human AMIGO1 (adhesion molecule with Ig like domain 1). PHENOTYPE: Mice homozygous for a null allele show a reduced size of retinal horizontal cell axons with no changes in the size of their dendrites or the ability of both arbors to form connections. The changes in horizontal cell axons are matched by changes in synaptic partner dendrites to stabilize retinal function. [provided by MGI curators] |