| Primary Identifier | MGI:1913500 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 99730 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Located in nucleus. Is expressed in several structures, including cranial ganglion; limb mesenchyme; sensory organ; submandibular gland primordium; and tail dorsal root ganglion. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 60. Orthologous to human TAF13 (TATA-box binding protein associated factor 13). PHENOTYPE: Mice homozygous for a knock-out allele reach the egg-cylinder stage but fail to initiate gastrulation and show embryonic growth retardation, a size reduction of the epiblast, extraembryonic ectoderm and pro-amniotic cavity, absence of the primitive node, head folds, allantois, amnion and chorion, and complete embryonic lethality prior to organogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
