| Primary Identifier | MGI:104995 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 14630 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables glutamate-cysteine ligase catalytic subunit binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; glutathione biosynthetic process; and negative regulation of extrinsic apoptotic signaling pathway. Part of glutamate-cysteine ligase complex. Is expressed in several structures, including alimentary system; liver; nervous system; urinary system; and vibrissa. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit). PHENOTYPE: Homozygotes for one null allele show reduced cysteine levels and increased cellular sensitivity to hydrogen peroxide. Homozygotes for another null allele show increased sensitivity to induced hepatotoxicity and neurotoxicity, and ovarian oxidative stress and accelerated ovarian failure in females. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
