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Protein Coding Gene : Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Primary Identifier  MGI:1932544 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  83398
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables N-acetylglucosamine deacetylase activity and [heparan sulfate]-glucosamine N-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including future brain; genitourinary system; heart; nervous system; and retina. Orthologous to human NDST3 (N-deacetylase and N-sulfotransferase 3).
PHENOTYPE: Mice homozygous for a knockout allele exhibit decreased anxiety-related behavior, cholesterol levels and CD8+ T cells due to moderate heparan-sulfate undersulfation. [provided by MGI curators]
  • synonyms:
  • 4921531K01Rik,
  • MGI:1921948,
  • 4930511P15Rik,
  • RIKEN cDNA 4930511P15 gene,
  • MGI:1918208,
  • Ndst3,
  • RIKEN cDNA 4921531K01 gene,
  • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
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