Primary Identifier | MGI:1890663 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 56811 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables co-receptor binding activity. Involved in negative regulation of Wnt signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Orthologous to human DKK2 (dickkopf WNT signaling pathway inhibitor 2). PHENOTYPE: mice homozygous for a targeted disruption are osteopenic with defective mineralization of induced osteoblasts in culture. [provided by MGI curators] |