| Primary Identifier | MGI:107164 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 19055 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of transport; and regulation of gene expression. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; calcineurin-NFAT signaling cascade; and regulation of DNA-templated transcription. Located in several cellular components, including Z disc; cytosol; and mitochondrion. Part of calcineurin complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; jaw; and thymus primordium. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha). PHENOTYPE: Mice homozygous for a null allele exhibit decreased T cell proliferation and abnormal mossy fibers. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
