| Primary Identifier | MGI:95305 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 13684 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA cap binding activity and translation initiation factor activity. Involved in mRNA export from nucleus; regulation of translation at postsynapse, modulating synaptic transmission; and translational initiation. Acts upstream of or within several processes, including behavioral fear response; cellular response to dexamethasone stimulus; and negative regulation of neuron differentiation. Located in chromatoid body and nuclear body. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; early conceptus; oocyte; polar body; and spleen. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E). PHENOTYPE: Mice homozygous for a knock-in allele exhibit resistance to developing prostate intraepithelial neoplasia. Embryos homozygous for a transposon-induced knock-out allele exhibit peri-implantation lethality, failure of normal epiblast formation, and decreased translational activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
