| Primary Identifier | MGI:1913283 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 56629 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA endonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Located in cytoplasm and extracellular region. Is expressed in ganglia; medulla oblongata basal plate mantle layer; and ventral grey horn. Used to study cataract. Orthologous to human DNASE2B (deoxyribonuclease 2 beta). PHENOTYPE: The inability of homozygous mutant mice to degrade DNA in differentiating lens cells leads to cataract formation in the nucleus lentis. Consequently, mutant mice exhibit an impaired response to light. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
