| Primary Identifier | MGI:87867 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 11364 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables medium-chain fatty acyl-CoA dehydrogenase activity. Involved in several processes, including carnitine metabolic process, CoA-linked; fatty acid metabolic process; and glycogen biosynthetic process. Acts upstream of or within several processes, including carnitine metabolic process; liver development; and response to cold. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study medium chain acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). PHENOTYPE: Mice homozygous for a knock-out allele display a high degree of postnatal lethality, develop an organic aciduria, fatty liver and an unexpected diffuse cardiomyopathy with multifocal myocyte degeneration and necrosis, and show severe cold intolerance with prior fasting. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
