| Primary Identifier | MGI:2676665 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 242274 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to postsynapse; and receptor clustering. Predicted to be located in actin cytoskeleton; dendritic spine; and filopodium. Predicted to be active in several cellular components, including axon initial segment; basolateral plasma membrane; and postsynaptic density membrane. Predicted to colocalize with postsynaptic membrane. Is expressed in brain; cortical plate; esophagus mesenchyme; spinal cord; and trachea mesenchyme. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human LRRC7 (leucine rich repeat containing 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit limb grasping, reduced long term depression, increased anxiety, increased aggression towards other mice, impaired spatial memory, decreased prepulse inhibition, decreased nesting building behavior, and abnormal dendritic spines. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
