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Protein Coding Gene : Tgs1 trimethylguanosine synthase 1
Primary Identifier  MGI:2151797 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  116940
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable RNA cap trimethylguanosine synthase activity. Predicted to be involved in 7-methylguanosine cap hypermethylation. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TGS1 (trimethylguanosine synthase 1).
PHENOTYPE: Mice homozygous for a null mutation display complete lethality around implantation with embryonic growth arrest, impaired hatching from the zona pellucida, and increased apoptosis. Null MEFs display G2 arrest. [provided by MGI curators]
  • synonyms:
  • nuclear receptor coactivator 6 interacting protein,
  • Ncoa6ip,
  • MGI:1289226,
  • D4Ertd800e,
  • DNA segment, Chr 4, ERATO Doi 800, expressed,
  • Tgs1,
  • Pimt,
  • trimethylguanosine synthase 1
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Canonical gene --> Transcripts in specific strains.

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