| Primary Identifier | MGI:97052 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 17451 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable MAP kinase kinase kinase activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of metaphase/anaphase transition of meiotic cell cycle; and positive regulation of MAPK cascade. Acts upstream of or within regulation of meiotic nuclear division. Located in cytoplasm. Is expressed in brain; early conceptus; gonad; large intestine; and metanephros. Orthologous to human MOS (MOS proto-oncogene, serine/threonine kinase). PHENOTYPE: Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
