Primary Identifier | MGI:2384791 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 208890 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chloride channel activity and chloride:bicarbonate antiporter activity. Involved in several processes, including bicarbonate transport; carboxylic acid transport; and inorganic anion transmembrane transport. Acts upstream of or within chloride transport. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; brain; limb; respiratory system; and sensory organ. Used to study congenital hypothyroidism. Orthologous to human SLC26A7 (solute carrier family 26 member 7). PHENOTYPE: Mice deficient for this marker have a reduce arterial pH and reduced serum bicarbonate. Urine is more concentrated and has an elevated pH. [provided by MGI curators] |