| Primary Identifier | MGI:1926471 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 60534 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including DNA damage response; ovarian follicle development; and spermatid development. Predicted to be located in several cellular components, including chromatin; mitochondrion; and nucleolus. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in gut dorsal mesentery and reproductive system. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group G; and pancreatic cancer. Orthologous to human FANCG (FA complementation group G). PHENOTYPE: Females and males homozygous for targeted null mutations exhibit hypogonadism and reduced fertility. Cytogeneic analysis showed somatic chromosome aberrations occur at a higher spontaneous rate and are easier to induce than in normal cells. Cells are also more sensitive to mitomycin C. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
