| Primary Identifier | MGI:1352457 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 18124 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and histone acetyltransferase binding activity. Involved in several processes, including cellular response to corticotropin-releasing hormone stimulus; positive regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regulation of apoptotic process. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; inner ear; and limb long bone. Human ortholog(s) of this gene implicated in extraskeletal myxoid chondrosarcoma. Orthologous to human NR4A3 (nuclear receptor subfamily 4 group A member 3). PHENOTYPE: Mice homozygous for a null allele exhibit defects in the semicircular canals of the inner ear and bidirectional circling behavior. Mice homozygous for another null allele display embryonic lethality with impaired cell migration during gastrulation. Homozygous KO also decreases apoptosis and increases proliferation of B cell stimulated by a single antigen. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
