| Primary Identifier | MGI:1928849 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 64817 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity and integrin binding activity involved in cell-matrix adhesion. Involved in positive regulation of platelet activation. Acts upstream of or within several processes, including Tie signaling pathway; lymph circulation; and lymph vessel morphogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver sinusoid; and respiratory system. Orthologous to human SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1). PHENOTYPE: Homozygous inactivation of this gene results in complete preweaning lethality, edema, abnormal skin coloration, thick epidermis, acanthosis, tail/limb abnormalities, and defects in lymphatic vascular development and valve formation. Heterozygosity for global or SMC-specific KO reduces aortic atherosclerotic plaque burden after high-fat diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
