Primary Identifier | MGI:2140340 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 100182 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity. Involved in several processes, including epithelial to mesenchymal transition; neuroblast delamination; and neuroblast division in subventricular zone. Located in centriole; centrosome; and microtubule. Is expressed in genitourinary system; hemolymphoid system; nervous system; respiratory system; and sensory organ. Orthologous to human AKNA (AT-hook transcription factor). PHENOTYPE: Mice homozygous for a hypomorphic or a knock-out allele exhibit partial postnatal lethality, pathogen-induced acute neutrophil responses leading to systemic inflammation and alveolar destruction, and increased susceptibility to fungal infection. [provided by MGI curators] |