| Primary Identifier | MGI:1098693 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 52463 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables DNA 5-methylcytosine dioxygenase activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dendrite morphogenesis; positive regulation of transcription by RNA polymerase II; and protein O-linked glycosylation. Acts upstream of or within epigenetic programing of male pronucleus; inner cell mass cell differentiation; and positive regulation of gene expression via chromosomal CpG island demethylation. Located in nucleus. Is expressed in several structures, including brain; early embryo; egg cylinder; genitourinary system; and immune system. Orthologous to human TET1 (tet methylcytosine dioxygenase 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit background sensitive lethality, abnormal forebrain development, abnormal female reproductive organs and decreased litter size. Mice homozygous for a different knock-out allele exhibit impaired adult neurogenesis, impaired spatial learning and impaired short-term memory retention. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
