| Primary Identifier | MGI:1918614 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 108829 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables protein demethylase activity. Involved in lipid biosynthetic process and plasma cell differentiation. Acts upstream of or within epithelial cell morphogenesis; male germ-line stem cell population maintenance; and seminiferous tubule development. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Predicted to be active in chromatin. Is expressed in several structures, including central nervous system; genitourinary system; heart; inner ear; and limb. Orthologous to human JMJD1C (jumonji domain containing 1C). PHENOTYPE: Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
