| Primary Identifier | MGI:1353627 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 30924 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme inhibitor activity. Involved in several processes, including cholesterol homeostasis; negative regulation of phospholipase activity; and phospholipid homeostasis. Located in Golgi apparatus; cell surface; and early endosome. Is expressed in several structures, including alimentary system; aorta; cartilage; liver and biliary system; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in familial hypobetalipoproteinemia 2. Orthologous to human ANGPTL3 (angiopoietin like 3). PHENOTYPE: Mice homozygous for a disruption in this gene display decreased plasma cholesterol and triglyceride levels. A spontaneous mutation results in a similar phenotype except that there is also a reduction in fat pad weight and decreased free fatty acid levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
