| Primary Identifier | MGI:1919935 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 72685 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable clathrin heavy chain binding activity and heat shock protein binding activity. Involved in synaptic vesicle uncoating. Acts upstream of or within clathrin coat disassembly and regulation of clathrin-dependent endocytosis. Located in postsynaptic density. Is extrinsic component of presynaptic endocytic zone membrane. Is expressed in genital tubercle of male; gut; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6). PHENOTYPE: Mice homozygous and heterozygous for a knock-out allele exhibit postnatal lethality and decreased body weight with homozygotes exhibiting decreased synpatic vesicle recycling. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
