| Primary Identifier | MGI:99557 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 18578 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables gamma-tubulin binding activity. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in several cellular components, including centrosome; postsynaptic density; and synaptic vesicle. Part of gamma-tubulin complex. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PDE4B (phosphodiesterase 4B). PHENOTYPE: Mice homozygous for disruptions in this gene produce significantly less TNF-alpha in response to lipopolysaccharide stimulation. One mutation resulted in brain and spinal cord vacuoles. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
