Primary Identifier | MGI:1927125 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 56296 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to be active in nucleus. Is expressed in brain; ovary; and testis. Orthologous to human DMRTB1 (DMRT like family B with proline rich C-terminal 1). PHENOTYPE: Male mice homozygous for a knock-out allele exhibit severe spermatogenesis defects, including a disruption of spermatogonial differentiation and a failure to complete meiotic prophase. [provided by MGI curators] |